ELISA TP63 anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:2A3 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regµLating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insµLts and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regµLation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regµLate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Immunogen:tumor protein p63 Synonyms:KET, P63, P73H, P73L, TP73L Observed MW:68 kDa Uniprot ID:Q9H3D4 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:8626 Research Area:Cancer