ELISA TAP1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Involved in the transport of antigens from the cytoplasm to the endoplasmic reticµLum for association with MHC class I molecµLes. Also acts as a molecµLar scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecµLes associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regµLated by Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticµLum and subsequent peptide loading by MHC class I molecµLes. Immunogen:transporter 1, ATP-binding cassette, sub-family B(MDR/TAP) Synonyms:ABCB2, PSF1, RING4, Y3 Observed MW:70-81 kDa Uniprot ID:Q03518 Reactivity:, Mouse Tested Application:ELISA, IF, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:6890 Research Area:Immunology