ELISA TOLLIP Antibody, HRP

Quantity :50µg Clone Number: Aliases:Adapter protein antibody; FLJ33531 antibody; IL 1RAcPIP antibody; IL1RAcPIP antibody; TOLIP antibody; TOLIP_ antibody; Toll interacting protein antibody; Toll-interacting protein antibody; tollip antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H0E2 Immunogen:Recombinant Toll-interacting protein (86-163AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjµgates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TOLLIP Research Areas:Immunology