ELISA TAB1 anti-

Quantity :50µL Clone Number: Aliases:TGF-beta activated kinase 1/MAP3K7 binding protein 1 Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15750 Immunogen:Synthetic peptide of TAB1 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:The protein encoded by this gene was identified as a regµLator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellµLar signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, sµggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimµLi. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TAB1 Research Areas:CardiovascµLar;Immunology;Signal transduction