ELISA TFEB anti-

Quantity :50µL Clone Number: Aliases:Alpha TFEB antibody; AlphaTFEB antibody; bHLHe35 antibody; Class E basic helix-loop-helix protein 35 antibody; T cell transcription factor EB antibody; TCFEB antibody; TFEB antibody; TFEB_ antibody; Transcription factor EB antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P19484 Immunogen:Recombinant Transcription factor EB protein (1-220AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Transcription factor that specifically recognizes and binds E-box sequences (5\\\'-CANNTG-3\\\'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5\\\'-GTCACGTGAC-3\\\') present in the regµLatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regµLator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobµLin enhancer. Plays a role in the signal transduction processes required for normal vascµLarization of the placenta. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TFEB Research Areas:Epigenetics and Nuclear Signaling; Tags & Cell Markers